Abstract: Objective To evaluate the difference of inflammatory factors in aqueous humor between patients with HBV positive cataract and normal cataract. Design experimental study. Participants Aqueous humor in 18 HBV positive cataract patients and 18 normal cataract patients. Methods Aqueous humor samples of all subjects were collected during cataract surgery, and 40 kinds of cytokines were detected using the human cytokine antibody array detection technology (Ray Biotech company). Main Outcome Measures Concentration of 40 inflammatory factors in aqueous humor. Results Among the 40 inflammatory factors of the aqueous humor between the HBV positive cataract patients and the normal cataract patients, there was a significant difference in the content of GM-CSF (0.559±0.134 pg/ml, 0.768±0.195 pg/ml), IL-5 (1.285±0.664 pg/ml, 1.854±0.896 pg/ml), IL-7 (5.076±1.112 pg/ml, 6.298±1.435 pg/ml), IL-17 (2.643±1.050 pg/ml, 3.643±1.659 pg/ml), PDGF-BB (0.367±0.297 pg/ml, 0.169±0.286 pg/ml), TNFα (6.912±2.697 pg/ml, 3.191±3.462 pg/ml), TNFβ (28.307±12.954 pg/ml, 17.424±12.741 pg/ml) (all P<0.05). Conclusion This small sample study showed that the expression of PDGF-BB, TNF α and TNF β in aqueous humor of HBV positive cataract patients was higher than that of normal cataract patients, and GM-CSF, IL-5, IL-7 and IL-17 were lower. The increased expression of PDGF-BB, TNF α and TNF β may be the reason why the patients with HBV positive cataract are more sensitive to intraoperative pain than those with normal cataract. (Ophthalmol CHN, 2020, 29: 69-72)

Key words: hepatitis B, cataract surgery, inflammatory factors of aqueous humor